Tobramycin ophthalmic (Tobrex)

Tobramycin and Dexamethasone ophthalmic (Tobradex)

Category:

• Antibiotic

Description:

• Aminoglycoside antibiotic

• Aminoglycoside and steroidal anti-inflammatory combination

Indications:

• Ocular infections due to susceptible organisms (see Tobramycin injection monograph) 

Contraindications:

• Generally not indicated for long-term therapy due to nephrotoxocity and ototoxicity

Precautions:

• Pregnancy category D

• Use proper ophthalmic application procedures (tilt head backward, pull lower eyelid downward to make a “cup”, avoid touching tip of bottle, drop in eye, place light pressure on lacrimal sac for ~1 minute)

• Ophthalmic suspension must be shaken prior to use

• Notify provider immediately at the first sign of skin rash or other allergic reaction

• Use of steroids in the presence of viral infections such as herpes, may prolong or worsen the severity of the viral infection.

Adverse Reactions (Side Effects):

• Transient irritation, burning or stinging

• May cause white crystalline precipitates and lid margin crusting

Dosage:

• Administered by ophthalmic drops, ointment and suspension (Tobradex)

• Instill 1-2 drops into affected eye(s) every 4 hours